Tenchijin is rapidly coming closer to its culmination. The young Hideyori has been born and the Toyotomi heir crisis is now coming to boil with Mitsunari confronting Hidetsugu with the charge that he is suspected of treason. Mitsunari's evil smile at the end of the episode after Hidetsugu accused him of causing his downfall shows that Mitsunari is now rapidly sliding into his manipulative and destructive ways and making many enemies.
Earlier, Mitsunari was confronted by several of the other great Daimyo, mainly Tokugawa Ieyasu and Mori Terumoto, who have accused Mitsunari of manipulating Hideyoshi and causing great hardship for the daimyo. Below is Ieyasu confronting Mitsunari. Ultimately it is Ieyasu versus Mitsunari in the epic confrontation at Sekigahara.
One of the enemies that Mitsunari makes that he will later truly regret is one of Hideyoshi's adopted sons, Hidetoshi. Mitsunari has Hidetoshi removed from any influence or power in the Toyotomi family by forcing the Mori clan to adopt Hidetoshi. This causes Hidetoshi great anger and hatred towards Mitsunari and he will eventually have his revenge against Mitsunari at the battle of Sekigahara. Below is Hidetoshi begging the Uesugi for assistance with his plight.